The Lowdown on Rejuran

The Lowdown on Rejuran

”Another blog on REJURAN® healer…???”

Yes, it might sound like a broken record, but hear us out… REJURAN® has been gaining so much popularity nowadays that almost every aesthetic clinic in Singapore seems to be recommending it. So, we feel it is necessary to break it down again. We will try not to overload you with too much information but at the end of the blog, you should know what you need to know about REJURAN®.

Why is REJURAN® so popular?

Simple answer to this is because it works….and it does not cost an arm or a leg to do the treatment, aka it is not expensive. Additionally, it also does not cost both arms and both legs for the clinic to provide the treatment, unlike some lasers, whereby the machine itself costs more than $200k to purchase.

Another reason why it’s so popular is because in Asia, there is such a big emphasis on attaining “flawless-looking” skin. Having a healthy skin is an essential building block for any other anti-ageing and aesthetics treatments.

Let’s start from the beginning.

What is it?

REJURAN® Healer or commonly known as “REJURAN®”, “PN (polynucleotides) treatment”, “PDRN therapy”, “baby skin injections” is now the MUST-HAVE treatment if you are dreaming of getting flawless skin. Originating from South Korea, REJURAN® healer is an anti-aging treatment that reverses signs of ageing and repairs damaged skin. Its “secret weapon” is PNs (polynucleotides) and PDRNs (Polydeoxyribonucleotides), extracted from salmon DNA.

How does it work?

OK, so this is where it gets quite technical…

As stated earlier, REJURAN® contains PNs and PDRNs. A polynucleotide molecule is essentially a molecule composed of 13 or more nucleotide monomers bonded in a chain.

What is nucleotide? Nucleotide is the basic structural unit of DNA.

What is DNA made of?
• DNA is a polymer made of repeating subunits called nucleotides.

• Nucleotides have three parts: a simple sugar, a phosphate group, and a nitrogenous base.

The nucleotide in REJURAN® is extracted from salmon germ cells…aka “sperm cells” and is known to have the most compatibility with human, as well as being safe and heat-resistant.


Polynucleotides (PNs) refer to a broader group of molecules. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are all PNs. On the other hand, PRDN – Polydeoxyribonucleotides, refer to a subtype of PNs. REJURAN® contains PNs – which also includes PDRN.

Polynucleotides containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration.

Polynucleotides work by:
1. Anti-inflammatory function – through fighting free radicals
2. Wound healing – growth factors stimulations and increased angiogenesis (formation of new blood vessels) which enhances circulation.

In medicine, PDRN and PNs have been used for clinical treatment of orthopaedic conditions, like chronic tendinosis as well as treatment of diabetic foot ulcers.

Long story short: REJURAN® contains substances extracted from salmon DNA that is compatible with our cells and hence able to stimulate cell regeneration for newer and younger looking skin, in addition to increasing skin hydration.

How safe is REJURAN® Treatment?

The treatment is fairly safe.

As for the ingredients of REJURAN®, we have not seen anybody who develops adverse reaction to REJURAN® Treatment. It does not trigger immune response due to the purified DNA fragment content. It is also developed in sterile aseptic condition and it is biocompatible with human cells as well.

Why bother? Who should get the treatment?

With age, our skin condition naturally will deteriorate. Additionally, our skin cells are constantly fighting pollutants, UV rays and free radicals that cause even more damage. After the age of 25, our skin steadily loses 1% of collagen and elastin.

REJURAN® will be beneficial for nearly everyone, no matter young, old, male, or female. But the types of patients that will benefit most from the treatment include:

1. Patients who have sensitive and thin skin
2. Patients with fine wrinkles all over the face
3. Patients who desire newer and healthy-looking skin
4. Patients with depressed acne scars
5. Patients with large and open pores
6. Patients who does not want filler or toxin

How to Prepare for the treatment? What to expect?

There really is no specific preparation that you need to do. It may however, helps if you stop supplements like ginkgo, vitamin E, ginseng or glucosamine 2-3 days before day of treatment as these supplements may cause increase risk of bruising, which means prolonged downtime after the treatment.

The recommended frequency of treatments is as follow:

Every 3-4 weeks for the first 3 treatments, followed by maintenance treatment every 3-6 months

This treatment protocol has been shown to give the most optimal results but it does not mean that if you miss your 4-weekly treatment, you will not get the result. But the result may not be as long as it is intended to be.

The treatment itself usually takes about 1-1.5 hours depending on your pain tolerance level. Application of numbing cream can be varied according to your needs. The injection itself usually takes 20-30 minutes for 2mL syringe.

After the treatment, you are left with multiple “insect-bite-like” swellings on treated area. These swellings usually range in size between 3mm – 8mm. By the end of the day, the swellings would usually subside and you are left with tiny injection marks, which if you need to cover can be covered by concealer/primer or foundation. These marks usually take 3-7 days to disappear.

So, if you are planning to do this treatment, try not to schedule any big event/dinner for the next few days after the treatment.

Results of REJURAN®

The benefits of REJURAN® include but not limited to the followings:

1. Smoothen skin texture
2. Reduce the size of pores
3. Improve acne scars
4. Reduce blemishes and breakouts
5. Improve skin hydration
6. Reverse signs of ageing
7. Restore skin elasticity

Is this really true????

A randomized double-blind clinical trial study conducted in 2014 showed patients who were treated with REJURAN® showed the greatest elasticity and collagen composition and a significant reduction in skin surface roughness and wrinkle depth at 12 weeks compared to the control group.

Promotion of skin cell growth and skin thickness

Improvement in Skin condition and brightness

Elasticity improvement

Different Types of REJURAN® Series

1. REJURAN® Healer

REJURAN® Healer is probably the most well-known type and all REJURAN® treatments initially originated from REJURAN® Healer. Most clinics in Singapore provide this type of REJURAN® instead of the other series.

Main ingredients: PNs(Polynucleotides)


REJURAN® I greatly reduces the signs of ageing around the eye area. It can be used to improve tear trough deformity and crow’s feet lines.

Main ingredients: PNs with low viscosity and high spreadability


REJURAN® S helps to improve the appearance of acne scars. With thicker viscosity, REJURAN® S promotes and boosts healing of acne scar tissues and help to fill up dents in scar and smoothens out the skin tissues.

Main ingredients: higher PNs content and higher viscosity material


REJURAN® HB or REJURAN® Hydro Boost has similar property of REJURAN® healer with additional bonus of hydrating effect of hyaluronic acids. This is ideal for those with problematic and dry skin.

Main ingredients: PNs and HAs(Hyaluronic Acids)

REJURAN® I and REJURAN® S are currently still pending product registration.

Can REJURAN® be combined with other treatments?

The short answer to this question is: YES.

However, always get your skin to be fully-evaluated by your doctor before he or she can decide if REJURAN® is suitable or if you will benefit further from combining it with other treatments.

Word of Caution

Obviously, this may sound too good to be true. However, we have seen firsthand how satisfied and happy patients are after seeing the results of REJURAN® itself. Hence, after years of treating patients with REJURAN®®, we still cannot stop recommending REJURAN® to our patients.

BUT… (There is always a but…), do note the followings:

1. Results may varied from one patient to another
2. The injections should only be done by experienced and trained practitioner, as where the material is placed may affect the end result
3. Do NOT be tricked by deals which are too good to be true. There are words of warning by the supplier that FAKE REJURAN® has been circulating in some clinics in Asia. So if the price is too good, the likelihood is that it really is too good to be true.

If you want to know about the differences between REJURAN® and skinboosters, you can read our post here

If you have any questions, please do not hesitate to drop me an email at [email protected].

Written By Dr. Shirley Kwee


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